What the FDA labels say about taking them together
Edoxaban and warfarin
Edoxaban's FDA label of July 10, 2025 names warfarin in its boxed warning section; the warfarin label PlainMeds reads does not name edoxaban. The edoxaban label: “In the randomized ENGAGE AF-TIMI 48 study, NVAF patients with CrCL > 95 mL/min had an increased rate of ischemic stroke with SAVAYSA 60 mg daily compared to patients treated with warfarin.”
Check it at the source: the edoxaban FDA label on DailyMed (effective July 10, 2025, Daiichi Sankyo Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the edoxaban label say about warfarin?
Edoxaban label, boxed warningIn the ENGAGE AF-TIMI 48 study, nonvalvular atrial fibrillation patients with CrCL > 95 mL/min had an increased rate of ischemic stroke with SAVAYSA 60 mg once daily compared to patients treated with warfarin.
Source: FDA drug label (SAVAYSA), Daiichi Sankyo Inc., effective July 10, 2025 (SPL set e77d3400-56ad-11e3-949a-0800200c9a66), via openFDA; the full label on DailyMed
What does the warfarin label say about edoxaban?
Warfarin's label (effective May 29, 2026) does not name edoxaban in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Edoxaban | Warfarin | |
|---|---|---|
| Labeled for | Atrial fibrillation, Stroke prevention, Blood clots (DVT and PE) | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $15.51 per tablet 60 mg tablet | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once