What the FDA labels say about taking them together
Duloxetine and thioridazine
Duloxetine's FDA label of May 14, 2024 names thioridazine in its drug interactions section; the thioridazine label PlainMeds reads does not name duloxetine. The duloxetine label: “Monitor blood pressure prior to initiating treatment and periodically throughout treatment Inhibitors of CYP1A2 or Thioridazine:”
Check it at the source: the duloxetine FDA label on DailyMed (effective May 14, 2024, SUN PHARMACEUTICAL INDUSTRIES, INC.); the thioridazine FDA label on DailyMed (effective November 11, 2025, Mylan Institutional Inc.).
What does the duloxetine label say about thioridazine?
Duloxetine label, drug interactionsExamples; TCAs (nortriptyline, amitriptyline, imipramine, desipramine); phenothiazines (thioridazine); Type 1C antiarrhythmics (propafenone, flecainide)
Duloxetine label, warnings and precautionsMonitor blood pressure prior to initiating treatment and periodically throughout treatment (5.11) Inhibitors of CYP1A2 or Thioridazine:
Source: FDA drug label (DRIZALMA SPRINKLE), SUN PHARMACEUTICAL INDUSTRIES, INC., effective May 14, 2024 (SPL set b41423b8-dfec-4d79-ba3c-e43a87803d85), via openFDA; the full label on DailyMed
What does the thioridazine label say about duloxetine?
Thioridazine's label (effective November 11, 2025) does not name duloxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Thioridazine Hydrochloride), Mylan Institutional Inc., effective November 11, 2025 (SPL set 52fea941-0b47-41c1-b00d-f88150e8ab93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Duloxetine | Thioridazine | |
|---|---|---|
| Labeled for | Depression, Anxiety, Nerve pain and fibromyalgia, Pain | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.102 per capsule 30 mg capsule | $0.571 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once