What the FDA labels say about taking them together
Duloxetine and linezolid
Duloxetine's FDA label of May 14, 2024 names linezolid in its contraindications section; linezolid's label does not name duloxetine itself but warns about its class (SNRIs (serotonin and norepinephrine reuptake inhibitors)). The duloxetine label: “Allow at least 5 days after stopping Duloxetine Delayed-Release Capsules prior to initiation of an MAOI to treat psychiatric disorders.. …”
Check it at the source: the duloxetine FDA label on DailyMed (effective May 14, 2024, SUN PHARMACEUTICAL INDUSTRIES, INC.); the linezolid FDA label on DailyMed (effective June 19, 2026, Hospira, Inc.).
What does the duloxetine label say about linezolid?
Duloxetine label, contraindicationsStarting DRIZALMA SPRINKLE in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is contraindicated because of an increased risk of serotonin syndrome [see Warnings and Precautions (5.4)].
Duloxetine label, drug interactionsExamples; Selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, intravenous methylene blue
Duloxetine label, warnings and precautionsIf it is necessary to initiate treatment with an MAOI such as linezolid or intravenous methylene blue in a patient taking DRIZALMA SPRINKLE, discontinue DRIZALMA SPRINKLE before initiating treatment with the MAOI [see Contraindications (4), Drug Interactions (7)].
Duloxetine label (Almatica Pharma LLC, March 2, 2026), contraindicationsAllow at least 5 days after stopping Duloxetine Delayed-Release Capsules prior to initiation of an MAOI to treat psychiatric disorders. [see Dosage and Administration ( 2.7 ), Warnings and Precautions ( 5.4 )]. who are using other MAOIs such as linezolid or intravenous methylene blue because of an increased risk of serotonin syndrome [see Dosage and Administration ( 2.8 ), Warnings and Precautions ( 5.4 )].
Duloxetine label (Almatica Pharma LLC, March 2, 2026), drug interactionsPrevention or Management; Concomitant use of Duloxetine Delayed-Release Capsules is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Dosage and Administration (,), Contraindications (), Warnings and Precautions ()].
Source: FDA drug label (Duloxetine, NDA219131), Almatica Pharma LLC, effective March 2, 2026 (SPL set bb2ca3bf-983c-1e4a-a91d-dc7dee66d741), via openFDA
Source: FDA drug label (DRIZALMA SPRINKLE), SUN PHARMACEUTICAL INDUSTRIES, INC., effective May 14, 2024 (SPL set b41423b8-dfec-4d79-ba3c-e43a87803d85), via openFDA; the full label on DailyMed
What does the linezolid label say about duloxetine?
Linezolid's label does not name duloxetine itself; it warns about its class (SNRIs (serotonin and norepinephrine reuptake inhibitors)):
Linezolid label, warnings and precautionsSpontaneous reports of serotonin syndrome including fatal cases associated with the concomitant use of linezolid and serotonergic agents have been reported. Commonly used serotonergic agents include serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, buspirone, serotonin 5-HT1 receptor agonists (triptans), and opioids, including meperidine.
Linezolid label, warnings and precautionsSpontaneous reports of serotonin syndrome including fatal cases associated with the concomitant use of ZYVOX and serotonergic agents have been reported. Commonly used serotonergic agents include serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, buspirone, serotonin 5‑HT1 receptor agonists (triptans), and opioids, including meperidine.
Source: FDA drug label (Linezolid), Hospira, Inc., effective June 19, 2026 (SPL set c401f1a8-cc37-461b-bfef-f2e156629bf8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Duloxetine | Linezolid | |
|---|---|---|
| Labeled for | Depression, Anxiety, Nerve pain and fibromyalgia, Pain | Bacterial infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.102 per capsule 30 mg capsule | $1.44 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once