What the FDA labels say about taking them together
Drospirenone/ethinyl estradiol/levomefolate and voriconazole
Drospirenone/ethinyl estradiol/levomefolate's FDA label of March 4, 2026 names voriconazole in its drug interactions section; the voriconazole labels PlainMeds reads (3) do not name drospirenone/ethinyl estradiol/levomefolate. The drospirenone/ethinyl estradiol/levomefolate label: “Concomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals, verapamil, macrolides, diltiazem, and grapefruit juice can increase the plasma concentrations of the estrogen or the …”
Check it at the source: the drospirenone/ethinyl estradiol/levomefolate FDA label on DailyMed (effective March 4, 2026, Bayer HealthCare Pharmaceuticals Inc.); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the drospirenone/ethinyl estradiol/levomefolate label say about voriconazole?
Drospirenone/ethinyl estradiol/levomefolate label, drug interactionsConcomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals (e.g., ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (e.g., clarithromycin, erythromycin), diltiazem, and grapefruit juice can increase the plasma concentrations of the estrogen or the progestin or both.
Drospirenone/ethinyl estradiol/levomefolate label, warnings and precautionsStrong CYP3A4 inhibitors include azole antifungals (e.g. ketoconazole, itraconazole, voriconazole), HIV/HCV protease inhibitors (e.g., indinavir, boceprevir), and clarithromycin [see Clinical Pharmacology (12.3 )].
Source: FDA drug label (Beyaz, NDA022532), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 8132454a-6135-4bac-b206-83a55eb8dbc6), via openFDA
Source: FDA drug label (Safyral), Bayer HealthCare Pharmaceuticals Inc., effective March 4, 2026 (SPL set 97563516-306a-4e17-9690-edbda49ecd83), via openFDA; the full label on DailyMed
What does the voriconazole label say about drospirenone/ethinyl estradiol/levomefolate?
Voriconazole's label (effective February 26, 2026) and its 2 other brand-application labels do not name drospirenone/ethinyl estradiol/levomefolate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/ethinyl estradiol/levomefolate | Voriconazole | |
|---|---|---|
| Labeled for | Birth control, Acne | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.38 per unit 3-0.02-0.451 | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once