What the FDA labels say about taking them together
Drospirenone/ethinyl estradiol and enalapril
Drospirenone/ethinyl estradiol's FDA label of May 29, 2025 names enalapril in its drug interactions section; the enalapril labels PlainMeds reads (2) do not name drospirenone/ethinyl estradiol.
Check it at the source: the drospirenone/ethinyl estradiol FDA label on DailyMed (effective May 29, 2025, Bayer HealthCare Pharmaceuticals Inc.); the enalapril FDA label on DailyMed (effective January 23, 2026, Bausch Health US LLC).
What does the drospirenone/ethinyl estradiol label say about enalapril?
Drospirenone/ethinyl estradiol label, drug interactionsA drug-drug interaction study of DRSP 3 mg/estradiol (E2) 1 mg versus placebo was performed in 24 mildly hypertensive postmenopausal women taking enalapril maleate 10 mg twice daily.
Source: FDA drug label (Yaz), Bayer HealthCare Pharmaceuticals Inc., effective May 29, 2025 (SPL set 065f33e4-b587-4e66-b896-ca9ab7b7c876), via openFDA; the full label on DailyMed
What does the enalapril label say about drospirenone/ethinyl estradiol?
Enalapril's label (effective January 23, 2026) and its 1 other brand-application label do not name drospirenone/ethinyl estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Vasotec), Bausch Health US LLC, effective January 23, 2026 (SPL set 39631f1f-5d19-43c1-b504-bf56d991ed97), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/ethinyl estradiol | Enalapril | |
|---|---|---|
| Labeled for | Acne, Birth control | High blood pressure, Heart failure |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.151 per tablet 3-0.03 mg tablet | $0.0664 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once