What the FDA labels say about taking them together
Drospirenone/estradiol and verapamil
Drospirenone/estradiol's FDA label of March 2, 2026 names verapamil in its drug interactions section; the verapamil labels PlainMeds reads (4) do not name drospirenone/estradiol. The drospirenone/estradiol label: “… administration of moderate or strong CYP3A4 inhibitors such as azole antifungals, verapamil, macrolides, diltiazem, and grapefruit juice did increase the plasma concentrations of the estrogen or the progestin or both. …”
Check it at the source: the drospirenone/estradiol FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the verapamil FDA label on DailyMed (effective April 6, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the drospirenone/estradiol label say about verapamil?
Drospirenone/estradiol label, drug interactions… increasing the exposure of estrogens and progestins (enzyme inhibitors) Concomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals (for example, ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (for example, clarithromycin, erythromycin), diltiazem, and grapefruit juice did increase the plasma concentrations of the estrogen or the progestin or both [see Warnings and Precautions (5.2) and Clinical Pharmacology (12.3) ]. …
Source: FDA drug label (Angeliq), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 761834c2-6b61-4583-84c2-f1ca4a97c4f2), via openFDA; the full label on DailyMed
What does the verapamil label say about drospirenone/estradiol?
Verapamil's label (effective April 6, 2026) and its 3 other brand-application labels do not name drospirenone/estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Verapamil hydrochloride), Zydus Pharmaceuticals (USA) Inc., effective April 6, 2026 (SPL set e19ab8d8-dae5-489d-9805-7e7407bea06d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/estradiol | Verapamil | |
|---|---|---|
| Labeled for | Menopause symptoms | High blood pressure, Atrial fibrillation, Angina |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $6.37 per tablet 0.25 mg-0.5 mg tablet | $0.191 per tablet 180 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once