Dronedarone · more major-labeled pairs than Diltiazem
SPL labels Dronedarone + Diltiazem as minor; Dronedarone 8 / Diltiazem 35 in that band.
Mechanism on file: These two drugs slow down each other's breakdown in the body. This causes the levels of both medications to rise at the same time.
FDA SPL severity: Minor
Dronedarone + Diltiazem · SPL mechanism field
These two drugs slow down each other's breakdown in the body. This causes the levels of both medications to rise at the same time.
Minor band excerpt · Dronedarone with Diltiazem
Calcium Channel Blockers Verapamil and diltiazem are moderate CYP3A inhibitors and increase dronedarone exposure. Calcium Channel Blockers Dronedarone increased the exposure of calcium channel blockers (verapamil, diltiazem or nifedipine).
Dronedarone · 9 major-labeled pairs (vs Diltiazem's 4)
- Dabigatran minor
- Digoxin minor
- Metoprolol minor
- Nifedipine minor
Diltiazem · 46 SPL pairs (broader portfolio than Dronedarone)
- Amiodarone minor
- Buspirone minor
- Carbamazepine minor
- Carvedilol minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.