Dronedarone · more major-labeled pairs than Digoxin
SPL labels Dronedarone + Digoxin as minor; Dronedarone 8 / Digoxin 105 in that band.
Mechanism on file: Dronedarone significantly increases the amount of digoxin in your blood, which can be very dangerous. Taking these two drugs together has been linked to a higher risk of sudden death in some patients.
FDA SPL severity: Minor
Dronedarone + Digoxin · SPL mechanism field
Dronedarone significantly increases the amount of digoxin in your blood, which can be very dangerous. Taking these two drugs together has been linked to a higher risk of sudden death in some patients.
Minor band excerpt · Dronedarone with Digoxin
Captopril 58% 39% Clarithromycin NA 70% Dronedarone NA 150% Gentamicin 129-212% NA Erythromycin 100% NA Itraconazole 80% NA Lapatinib NA 180% Propafenone NA 60-270% Quinidine 100% NA Ranolazine 50% NA Ritonavir NA 86% Telaprevir 50% 85% Tetracycline 100% NA Verapamil 50-75% NA Digoxin concentrations increased less than 50% Atorvastatin 22% 15% Carvedilol 16% 14% Measure serum digoxin concentrations before initiating concomitant drugs. Dronedarone Sudden death was more common in patients receiving digoxin with dronedarone than on either alone; it is not clear whether this represents an...
Dronedarone · 9 major-labeled pairs (vs Digoxin's 2)
- Dabigatran minor
- Diltiazem minor
- Metoprolol minor
- Nifedipine minor
Digoxin · 120 SPL pairs (broader portfolio than Dronedarone)
- Acarbose minor
- Albuterol minor
- Amiodarone minor
- Atorvastatin minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.