What the FDA labels say about taking them together
Dronedarone and metoprolol
Dronedarone's FDA label of May 29, 2025 names metoprolol in its drug interactions section; the metoprolol labels PlainMeds reads (4) do not name dronedarone. The dronedarone label: “Beta-Blockers and Other CYP2D6 Substrates Dronedarone increased the exposure of propranolol and metoprolol.”
Check it at the source: the dronedarone FDA label on DailyMed (effective May 29, 2025, Sanofi-Aventis U.S. LLC); the metoprolol FDA label on DailyMed (effective March 3, 2026, Melinta Therapeutics, LLC).
What does the dronedarone label say about metoprolol?
Dronedarone label, drug interactionsBeta-Blockers and Other CYP2D6 Substrates Dronedarone increased the exposure of propranolol and metoprolol.
Source: FDA drug label (Multaq), Sanofi-Aventis U.S. LLC, effective May 29, 2025 (SPL set 7fa41601-7fb5-4155-8e50-2ae903f0d2d6), via openFDA; the full label on DailyMed
What does the metoprolol label say about dronedarone?
Metoprolol's label (effective March 3, 2026) and its 3 other brand-application labels do not name dronedarone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TOPROL XL), Melinta Therapeutics, LLC, effective March 3, 2026 (SPL set 496ddfaa-7c9c-4888-b747-a210249b367a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dronedarone | Metoprolol | |
|---|---|---|
| Labeled for | n/a | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $13.19 per tablet 400 mg tablet | $0.085 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once