What the FDA labels say about taking them together
Doxycycline and minocycline
Doxycycline's FDA label (Oracea) of April 16, 2025 names minocycline in its drug interactions section; the minocycline labels PlainMeds reads (4) do not name doxycycline. The doxycycline label: “Since both oral retinoids, including isotretinoin and acitretin, and the tetracyclines, primarily minocycline, can cause increased intracranial pressure, the concurrent use of an oral retinoid and a tetracycline should …”
Check it at the source: the doxycycline FDA label on DailyMed (effective July 25, 2025, Chartwell RX, LLC.); the minocycline FDA label on DailyMed (effective April 2, 2026, Torrent Pharmaceuticals Limited).
What does the doxycycline label say about minocycline?
Oracea label (Galderma Laboratories, L.P., April 16, 2025), drug interactionsSince both oral retinoids, including isotretinoin and acitretin, and the tetracyclines, primarily minocycline, can cause increased intracranial pressure, the concurrent use of an oral retinoid and a tetracycline should be avoided.
Source: FDA drug label (Oracea, NDA050805), Galderma Laboratories, L.P., effective April 16, 2025 (SPL set aa15c93a-ff4c-447a-8a21-96da506d8997), via openFDA
Source: FDA drug label (Doxycycline Monohydrate), Chartwell RX, LLC., effective July 25, 2025 (SPL set 02aa8731-d40f-43d8-8b63-a79a0503f8db), via openFDA; the full label on DailyMed
What does the minocycline label say about doxycycline?
Minocycline's label (effective April 2, 2026) and its 3 other brand-application labels do not name doxycycline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Minocycline Hydrochloride), Torrent Pharmaceuticals Limited, effective April 2, 2026 (SPL set 55df55fb-18ec-4e00-9ed0-10bba0da513b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Doxycycline | Minocycline | |
|---|---|---|
| Labeled for | Urinary tract infections, Bacterial infections, Acne | Urinary tract infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.118 per tablet 100 mg tablet | $0.343 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once