What the FDA labels say about taking them together
Doxepin and phenelzine
Phenelzine's FDA label of June 6, 2025 names doxepin in its warnings section; doxepin's label does not name phenelzine itself but warns about its class (MAO inhibitors).
Check it at the source: the doxepin FDA label on DailyMed (effective December 30, 2025, Leading Pharma, LLC); the phenelzine FDA label on DailyMed (effective June 6, 2025, Parke-Davis Div of Pfizer Inc).
What does the doxepin label say about phenelzine?
Doxepin's label does not name phenelzine itself; it warns about its class (MAO inhibitors):
Doxepin label, contraindicationsCONTRAINDICATIONS Hypersensitivity to doxepin hydrochloride, inactive ingredients, or other dibenzoxepines. ( 4.1 ) Co-administration with Monoamine Oxidase Inhibitors (MAOIs):
Doxepin label, contraindicationsCo-administration with Monoamine Oxidase Inhibitors (MAOIs) Serious side effects and even death have been reported following the concomitant use of certain drugs with MAO inhibitors.
Source: FDA drug label (DOXEPIN HYDROCHLORIDE), Leading Pharma, LLC, effective December 30, 2025 (SPL set e6a4cb10-1928-4abe-8797-404c9ddc37dd), via openFDA; the full label on DailyMed
What does the phenelzine label say about doxepin?
Phenelzine label, warningsA List of Dibenzazepine Derivative Drugs by Generic Name Follows: nortriptyline hydrochloride amitriptyline hydrochloride perphenazine and amitriptyline hydrochloride clomipramine hydrochloride desipramine hydrochloride imipramine hydrochloride doxepin carbamazepine cyclobenzaprine HCl amoxapine maprotiline HCl trimipramine maleate protriptyline HCl mirtazapine NARDIL should be used with caution in combination with antihypertensive drugs, including thiazide diuretics and β-blockers, since exaggerated hypotensive effects may result.
Source: FDA drug label (Nardil), Parke-Davis Div of Pfizer Inc, effective June 6, 2025 (SPL set 513a41d0-37d4-4355-8a6d-a2c643bce6fa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Doxepin | Phenelzine | |
|---|---|---|
| Labeled for | Depression, Anxiety, Eczema (atopic dermatitis), Insomnia | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0779 per capsule 10 mg capsule | $0.586 per tablet 15 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once