What the FDA labels say about taking them together
Dobutamine and entacapone
Dobutamine's FDA label of June 3, 2026 names entacapone in its drug interactions section, and entacapone's label names dobutamine too. The dobutamine label: “Concomitant use of dobutamine and catechol- O -methyltranferase (COMT) inhibitors (e.g., entacapone) may result in increased heart rate, arrhythmias, and changes in blood pressure.”
Check it at the source: the dobutamine FDA label on DailyMed (effective June 3, 2026, Hospira, Inc.); the entacapone FDA label on DailyMed (effective November 30, 2023, Sandoz Inc).
What does the dobutamine label say about entacapone?
Dobutamine label, drug interactionsConcomitant use of dobutamine and catechol- O -methyltranferase (COMT) inhibitors (e.g., entacapone) may result in increased heart rate, arrhythmias, and changes in blood pressure.
Source: FDA drug label (Dobutamine in Dextrose), Hospira, Inc., effective June 3, 2026 (SPL set 9943a961-3b50-4847-8a84-d8414ce38daa), via openFDA; the full label on DailyMed
What does the entacapone label say about dobutamine?
Entacapone label, warningsTherefore, drugs known to be metabolized by COMT, such as isoproterenol, epinephrine, norepinephrine, dopamine, dobutamine, alpha-methyldopa, apomorphine, isoetherine and bitolterol should be administered with caution in patients receiving entacapone regardless of the route of administration (including inhalation), as their interaction may result in increased heart rates, possible arrhythmias and excessive changes in blood pressure.
Source: FDA drug label (Entacapone), NDA020796 (Orion Pharma), as published by Sandoz Inc, effective November 30, 2023 (SPL set ad4b6d79-efd3-4c43-b4dc-5afdacf939a4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dobutamine | Entacapone | |
|---|---|---|
| Labeled for | n/a | Parkinson's disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.325 per tablet 200 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once