What the FDA labels say about taking them together
Diltiazem and silodosin
Silodosin's FDA label of April 15, 2026 names diltiazem in its drug interactions section; the diltiazem labels PlainMeds reads (4) do not name silodosin. The silodosin label: “Concomitant administration with moderate CYP3A4 inhibitors may increase concentration of silodosin.”
Check it at the source: the diltiazem FDA label on DailyMed (effective August 7, 2026, Bausch Health US, LLC); the silodosin FDA label on DailyMed (effective April 15, 2026, Amneal Pharmaceuticals NY LLC).
What does the diltiazem label say about silodosin?
Diltiazem's label (effective August 7, 2026) and its 3 other brand-application labels do not name silodosin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
What does the silodosin label say about diltiazem?
Silodosin label, drug interactionsConcomitant administration with moderate CYP3A4 inhibitors (e.g., diltiazem, erythromycin, verapamil) may increase concentration of silodosin.
Source: FDA drug label (Silodosin), Amneal Pharmaceuticals NY LLC, effective April 15, 2026 (SPL set de619e27-9384-4b86-abdc-de0557cd39e8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diltiazem | Silodosin | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Atrial fibrillation | Enlarged prostate (BPH) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.144 per capsule 24h ER(cd) 120 mg capsule | $0.319 per capsule 8 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once