What the FDA labels say about taking them together
Diltiazem and naloxegol
Naloxegol's FDA label of September 1, 2026 names diltiazem in its drug interactions section; the diltiazem labels PlainMeds reads (4) do not name naloxegol. The naloxegol label: “•Avoid use with moderate CYP3A4 inhibitors; if unavoidable, decrease the dosage of MOVANTIK to 12.5 mg once daily and monitor for adverse reactions.”
Check it at the source: the diltiazem FDA label on DailyMed (effective August 7, 2026, Bausch Health US, LLC); the naloxegol FDA label on DailyMed (effective September 1, 2026, Averitas Pharma, Inc.).
What does the diltiazem label say about naloxegol?
Diltiazem's label (effective August 7, 2026) and its 3 other brand-application labels do not name naloxegol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
What does the naloxegol label say about diltiazem?
Naloxegol label, drug interactionsConcomitant Agent: •Moderate CYP3A4 inhibitors (e.g., diltiazem, erythromycin, verapamil); Mechanism of Action: •Increase plasma naloxegol concentrations and may increase the risk of adverse reactions [see ].; Clinical Recommendation: •Avoid use with moderate CYP3A4 inhibitors; if unavoidable, decrease the dosage of MOVANTIK to 12.5 mg once daily and monitor for adverse reactions [see ].
Source: FDA drug label (MOVANTIK), Averitas Pharma, Inc., effective September 1, 2026 (SPL set 28596788-b73f-4247-85fc-3105f51fff5a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diltiazem | Naloxegol | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Atrial fibrillation | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.144 per capsule 24h ER(cd) 120 mg capsule | $14.61 per tablet 25 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once