What the FDA labels say about taking them together
Diltiazem and drospirenone/estradiol
Drospirenone/estradiol's FDA label of March 2, 2026 names diltiazem in its drug interactions section; the diltiazem labels PlainMeds reads (4) do not name drospirenone/estradiol. The drospirenone/estradiol label: “… strong CYP3A4 inhibitors such as azole antifungals, verapamil, macrolides, diltiazem, and grapefruit juice did increase the plasma concentrations of the estrogen or the progestin or both. …”
Check it at the source: the diltiazem FDA label on DailyMed (effective August 7, 2026, Bausch Health US, LLC); the drospirenone/estradiol FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.).
What does the diltiazem label say about drospirenone/estradiol?
Diltiazem's label (effective August 7, 2026) and its 3 other brand-application labels do not name drospirenone/estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
What does the drospirenone/estradiol label say about diltiazem?
Drospirenone/estradiol label, drug interactions… inhibitors) Concomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals (for example, ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (for example, clarithromycin, erythromycin), diltiazem, and grapefruit juice did increase the plasma concentrations of the estrogen or the progestin or both [see Warnings and Precautions (5.2) and Clinical Pharmacology (12.3) ]. …
Source: FDA drug label (Angeliq), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 761834c2-6b61-4583-84c2-f1ca4a97c4f2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diltiazem | Drospirenone/estradiol | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Atrial fibrillation | Menopause symptoms |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.144 per capsule 24h ER(cd) 120 mg capsule | $6.37 per tablet 0.25 mg-0.5 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once