What the FDA labels say about taking them together
Dihydroergotamine and voriconazole
Voriconazole's FDA label of February 26, 2026 names dihydroergotamine in its contraindications section; the dihydroergotamine labels PlainMeds reads (4) do not name voriconazole. The voriconazole label: “Coadministration of Voriconazole for injection with ergot alkaloids is contraindicated because Voriconazole for injection may increase the plasma concentration of ergot alkaloids, which may lead to ergotism.”
Check it at the source: the dihydroergotamine FDA label on DailyMed (effective March 6, 2025, Oceanside Pharmaceuticals); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the dihydroergotamine label say about voriconazole?
Dihydroergotamine's label (effective March 6, 2025) and its 3 other brand-application labels do not name voriconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dihydroergotamine Mesylate), NDA020148 (Bausch), as published by Oceanside Pharmaceuticals, effective March 6, 2025 (SPL set 977de209-c53a-4cb4-9f3f-1e850600a9dc), via openFDA; the full label on DailyMed
What does the voriconazole label say about dihydroergotamine?
Voriconazole label, contraindicationsErgot alkaloids (e.g., ergotamine, dihydroergotamine)
Voriconazole label (Xellia Pharmaceuticals USA LLC, January 11, 2023), contraindicationsCoadministration of Voriconazole for injection with ergot alkaloids (ergotamine and dihydroergotamine) is contraindicated because Voriconazole for injection may increase the plasma concentration of ergot alkaloids, which may lead to ergotism [see Drug Interactions (7) ].
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dihydroergotamine | Voriconazole | |
|---|---|---|
| Labeled for | Migraine | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $29.44 per mL 4 mg/mL nasal spray | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once