What the FDA labels say about taking them together
Digoxin and zoledronic acid
Zoledronic acid's FDA label (Reclast) of February 3, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name zoledronic acid. The zoledronic acid label: “In patients with renal impairment, the exposure to concomitant medications that are primarily renally excreted (e.g., digoxin) may increase.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the zoledronic acid FDA label on DailyMed (effective November 15, 2023, Gland Pharma Limited).
What does the digoxin label say about zoledronic acid?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name zoledronic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the zoledronic acid label say about digoxin?
Reclast label (Sandoz Inc, February 3, 2026), drug interactionsIn patients with renal impairment, the exposure to concomitant medications that are primarily renally excreted (e.g., digoxin) may increase.
Source: FDA drug label (Reclast, NDA021817), Sandoz Inc, effective February 3, 2026 (SPL set 5a9b3737-9ce6-4a89-b76e-6aab79eba9cf), via openFDA
Source: FDA drug label (Zoledronic Acid), Gland Pharma Limited, effective November 15, 2023 (SPL set 7a5e8962-7c4b-40bb-ad69-0c3edb0338af), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Zoledronic acid | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Osteoporosis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.475 per mL 5 mg/100 mL |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once