What the FDA labels say about taking them together
Digoxin and vonoprazan
Vonoprazan's FDA label of July 16, 2026 names digoxin in its warnings and precautions section; the digoxin labels PlainMeds reads (3) do not name vonoprazan. The vonoprazan label: “Consider monitoring magnesium and calcium levels in at-risk patients, or if there is concomitant use of digoxin or other drugs that cause hypomagnesemia. Interactions with Investigations for Neuroendocrine Tumors:”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the vonoprazan FDA label on DailyMed (effective July 16, 2026, Phathom Pharmaceuticals Inc.).
What does the digoxin label say about vonoprazan?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name vonoprazan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the vonoprazan label say about digoxin?
Vonoprazan label, warnings and precautionsConsider monitoring magnesium and calcium levels in at-risk patients, or if there is concomitant use of digoxin or other drugs that cause hypomagnesemia. ( 5.7 ) Interactions with Investigations for Neuroendocrine Tumors:
Source: FDA drug label (VOQUEZNA), Phathom Pharmaceuticals Inc., effective July 16, 2026 (SPL set 0cc52ac5-77ec-4d66-a770-762a1a960914), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Vonoprazan | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $22.41 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once