What the FDA labels say about taking them together
Digoxin and succinylcholine
Digoxin's FDA label of December 5, 2024 names succinylcholine in its drug interactions section; the succinylcholine labels PlainMeds reads (2) do not name digoxin.
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the succinylcholine FDA label on DailyMed (effective August 18, 2026, Hospira, Inc.).
What does the digoxin label say about succinylcholine?
Digoxin label, drug interactionsNeuromuscular Blocking Agents; Succinylcholine; May cause sudden extrusion of potassium from muscle cells causing arrhythmias in patients taking digoxin.
Source: FDA drug label (Digoxin, NDA021648), Hikma Pharmaceuticals USA Inc., effective April 10, 2025 (SPL set 1b7e5c6e-e052-41b0-a4ce-05dfe62faaaf), via openFDA
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the succinylcholine label say about digoxin?
Succinylcholine's label (effective August 18, 2026) and its 1 other brand-application label do not name digoxin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (QUELICIN), Hospira, Inc., effective August 18, 2026 (SPL set fb08161e-7711-406d-e7b3-ea4515c07983), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Succinylcholine | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once