What the FDA labels say about taking them together
Digoxin and sotagliflozin
Sotagliflozin's FDA label of August 12, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name sotagliflozin. The sotagliflozin label: “DRUG INTERACTIONS Digoxin: Monitor digoxin levels. Uridine 5'-diphospho-glucuronosyltransferase Inducers (e.g., rifampin):”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the sotagliflozin FDA label on DailyMed (effective August 12, 2026, Lexicon Pharmaceuticals, Inc.).
What does the digoxin label say about sotagliflozin?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name sotagliflozin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the sotagliflozin label say about digoxin?
Sotagliflozin label, drug interactionsDRUG INTERACTIONS Digoxin: Monitor digoxin levels. ( 7.1 ) Uridine 5'-diphospho-glucuronosyltransferase Inducers (e.g., rifampin):
Source: FDA drug label (INPEFA), Lexicon Pharmaceuticals, Inc., effective August 12, 2026 (SPL set 1a46614e-05f6-421a-b6f4-d6f8760d643a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Sotagliflozin | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Heart failure |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $20.37 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once