What the FDA labels say about taking them together
Digoxin and ranolazine
Ranolazine's FDA label of January 23, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name ranolazine. The ranolazine label: “Drugs transported by P-gp (e.g., digoxin), or drugs metabolized by CYP2D6 may need reduced doses when used with ranolazine.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the ranolazine FDA label on DailyMed (effective January 23, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the digoxin label say about ranolazine?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name ranolazine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the ranolazine label say about digoxin?
Ranolazine label, drug interactionsDrugs transported by P-gp (e.g., digoxin), or drugs metabolized by CYP2D6 (e.g., tricyclic antidepressants) may need reduced doses when used with ranolazine.
Aspruzyo Sprinkle label (SUN PHARMACEUTICAL INDUSTRIES, INC., January 29, 2025), drug interactionsDoses of other OCT2 substrates may require adjusted doses. (7.2) Drugs transported by P-gp (e.g., digoxin), or drugs metabolized by CYP2D6 (e.g., tricyclic antidepressants) may need reduced doses when used with ASPRUZYO Sprinkle.
Source: FDA drug label (Aspruzyo Sprinkle, NDA216018), SUN PHARMACEUTICAL INDUSTRIES, INC., effective January 29, 2025 (SPL set dd9f81e4-50da-4551-aed5-559d304df42e), via openFDA
Source: FDA drug label (Ranolazine), Glenmark Pharmaceuticals Inc., USA, effective January 23, 2026 (SPL set 0cf58732-c242-49b0-8e3f-248778b4458d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Ranolazine | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.165 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once