What the FDA labels say about taking them together
Digoxin and potassium chloride/sodium chloride
Potassium chloride/sodium chloride's FDA label of January 11, 2019 names digoxin in its warnings section; the digoxin labels PlainMeds reads (3) do not name potassium chloride/sodium chloride. The potassium chloride/sodium chloride label: “• with conditions predisposing to hyperkalemia and/or associated with increased sensitivity to potassium, such as patients with severe renal impairment, acute dehydration, extensive tissue injury or burns, certain …”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the potassium chloride/sodium chloride FDA label on DailyMed (effective January 11, 2019, Baxter Healthcare Company).
What does the digoxin label say about potassium chloride/sodium chloride?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name potassium chloride/sodium chloride in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the potassium chloride/sodium chloride label say about digoxin?
Potassium chloride/sodium chloride label, warnings• with conditions predisposing to hyperkalemia and/or associated with increased sensitivity to potassium, such as patients with severe renal impairment, acute dehydration, extensive tissue injury or burns, certain cardiac disorders such as congestive heart failure or atrioventricular (AV) block (especially if they receive digoxin).
Source: FDA drug label (Potassium Chloride in Sodium Chloride), Baxter Healthcare Company, effective January 11, 2019 (SPL set becc7410-0a25-49f5-b0c3-240078479dc8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Potassium chloride/sodium chloride | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once