What the FDA labels say about taking them together
Digoxin and paroxetine
Paroxetine's FDA label (Brisdelle) of April 28, 2025 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name paroxetine. The paroxetine label: “Digoxin Decreased plasma concentrations of digoxin The digoxin dosage of may need to be increased. Monitor digoxin concentrations and clinical effect.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.).
What does the digoxin label say about paroxetine?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name paroxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the paroxetine label say about digoxin?
Brisdelle label (Legacy Pharma USA, Inc., April 28, 2025), drug interactionsDigoxin Decreased plasma concentrations of digoxin The digoxin dosage of may need to be increased. Monitor digoxin concentrations and clinical effect.
Source: FDA drug label (Brisdelle, NDA204516), Legacy Pharma USA, Inc., effective April 28, 2025 (SPL set 502311b3-b617-4cbd-a3ab-a60f2c62880a), via openFDA
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Paroxetine | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Depression, Anxiety, Menopause symptoms |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.0611 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once