What the FDA labels say about taking them together
Digoxin and milnacipran
Milnacipran's FDA label of September 10, 2025 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name milnacipran.
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the milnacipran FDA label on DailyMed (effective September 10, 2025, Allergan, Inc.).
What does the digoxin label say about milnacipran?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name milnacipran in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the milnacipran label say about digoxin?
Milnacipran label, drug interactionsInteractions with Select Cardiovascular Agents Digoxin: Use of SAVELLA concomitantly with digoxin may be associated with potentiation of adverse hemodynamic effects.
Source: FDA drug label (Savella), NDA022256 (Abbvie), as published by Allergan, Inc., effective September 10, 2025 (SPL set 16a4a314-f97e-4e91-95e9-576a3773d284), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Milnacipran | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Nerve pain and fibromyalgia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $2.82 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once