What the FDA labels say about taking them together
Digoxin and mannitol
Mannitol's FDA label of August 26, 2025 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name mannitol. The mannitol label: “The development of electrolyte imbalances associated with mannitol administration may result in cardiac adverse reactions in patients receiving drugs that are sensitive to such imbalances.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the mannitol FDA label on DailyMed (effective August 26, 2025, Baxter Healthcare Company).
What does the digoxin label say about mannitol?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name mannitol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the mannitol label say about digoxin?
Mannitol label, drug interactionsAffected by Electrolyte Imbalances The development of electrolyte imbalances (e.g., hyperkalemia, hypokalemia) associated with mannitol administration may result in cardiac adverse reactions in patients receiving drugs that are sensitive to such imbalances (e.g., digoxin, drugs that prolong the QT interval, neuromuscular blocking agents) [see Warnings and Precautions (5.4) ].
Mannitol label, warnings and precautionsThe development of electrolyte imbalances (e.g., hyperkalemia, hypokalemia) associated with mannitol administration may result in cardiac adverse reactions in patients receiving drugs that are sensitive to such imbalances (e.g., digoxin, agents that may cause QT prolongation, neuromuscular blocking agents) [see Drug Interactions (7.4) ].
Source: FDA drug label (Osmitrol), Baxter Healthcare Company, effective August 26, 2025 (SPL set 0d914965-7001-45cb-ba51-d7c5964b05bc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Mannitol | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Edema (fluid retention) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once