What the FDA labels say about taking them together
Digoxin and lenacapavir
Lenacapavir's FDA label of August 27, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name lenacapavir. The lenacapavir label: “Use with caution and monitor digoxin therapeutic concentration.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the lenacapavir FDA label on DailyMed (effective August 27, 2026, Gilead Sciences, Inc.).
What does the digoxin label say about lenacapavir?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name lenacapavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the lenacapavir label say about digoxin?
Lenacapavir label, drug interactionsConcomitant Drug Class/Drug Name: Antiarrhythmics: digoxin; Effect on Concentration ↑ = Increase, ↓ = Decrease.: ↑ digoxin; Clinical Comment: Use with caution and monitor digoxin therapeutic concentration.
Source: FDA drug label (Sunlenca), Gilead Sciences, Inc., effective August 27, 2026 (SPL set e5652804-29c4-40d7-aeb2-0142ed2a7b5b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Lenacapavir | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once