What the FDA labels say about taking them together
Digoxin and ketorolac
Ketorolac's FDA label (Sprix) of December 5, 2024 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name ketorolac. The ketorolac label: “The concomitant use of ketorolac with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the ketorolac FDA label on DailyMed (effective August 31, 2023, Fresenius Kabi USA, LLC).
What does the digoxin label say about ketorolac?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name ketorolac in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the ketorolac label say about digoxin?
Sprix label (Zyla Life Sciences US LLC, December 5, 2024), drug interactionsClinical Impact: The concomitant use of ketorolac with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Intervention: During concomitant use of SPRIX and digoxin, monitor serum digoxin levels.
Source: FDA drug label (Sprix, NDA022382), Zyla Life Sciences US LLC, effective December 5, 2024 (SPL set 97005a1c-167e-4676-bae7-e49b38c36f9e), via openFDA
Source: FDA drug label (Ketorolac Tromethamine), Fresenius Kabi USA, LLC, effective August 31, 2023 (SPL set 3d88cbe6-5230-47aa-80af-0c41283d1f00), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Ketorolac | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $1.02 per mL 30 mg/mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once