What the FDA labels say about taking them together
Digoxin and gepotidacin
Gepotidacin's FDA label of February 10, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name gepotidacin. The gepotidacin label: “Due to an increase in digoxin exposures, consider monitoring digoxin serum concentration, as appropriate, with concomitant administration of BLUJEPA.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the gepotidacin FDA label on DailyMed (effective February 10, 2026, GlaxoSmithKline LLC).
What does the digoxin label say about gepotidacin?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name gepotidacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the gepotidacin label say about digoxin?
Gepotidacin label, drug interactionsDue to an increase in digoxin exposures, consider monitoring digoxin serum concentration, as appropriate, with concomitant administration of BLUJEPA.
Source: FDA drug label (Blujepa), GlaxoSmithKline LLC, effective February 10, 2026 (SPL set 80b57cfe-7819-4d95-a57d-014af42f118d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Gepotidacin | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Urinary tract infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $91.40 per tablet 750 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once