What the FDA labels say about taking them together
Digoxin and ferric oxyhydroxide
Ferric oxyhydroxide's FDA label of April 1, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name ferric oxyhydroxide.
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the ferric oxyhydroxide FDA label on DailyMed (effective April 1, 2026, Fresenius Medical Care Renal Therapies Group, LLC).
What does the digoxin label say about ferric oxyhydroxide?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name ferric oxyhydroxide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the ferric oxyhydroxide label say about digoxin?
Ferric oxyhydroxide label, drug interactionsDRUG INTERACTIONS Table 1 Oral drugs that can be administered concomitantly with Velphoro Calcitriol Ciprofloxacin Digoxin Enalapril Furosemide HMG-CoA reductase inhibitors Hydrochlorothiazide Losartan Metoprolol Nifedipine Omeprazole Quinidine Warfarin Oral drugs that are to be separated from Velphoro Dosing Recommendations Doxycycline Acetylsalicylic acid Cephalexin Take at least 1 hour before Velphoro.
Source: FDA drug label (Velphoro), Fresenius Medical Care Renal Therapies Group, LLC, effective April 1, 2026 (SPL set 237da26c-f38c-4faa-93ad-735e71c9d0c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Ferric oxyhydroxide | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $17.11 per tablet 500 mg chewable tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once