What the FDA labels say about taking them together
Digoxin and fenoprofen
Fenoprofen's FDA label of August 20, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name fenoprofen. The fenoprofen label: “The concomitant use of fenoprofen with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the fenoprofen FDA label on DailyMed (effective August 20, 2026, Misemer Pharmaceuticals, Inc.).
What does the digoxin label say about fenoprofen?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name fenoprofen in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the fenoprofen label say about digoxin?
Fenoprofen label, drug interactionsClinical Impact: The concomitant use of fenoprofen with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Intervention: During concomitant use of FENOPROFEN CALCIUM and digoxin, monitor serum digoxin levels.
Source: FDA drug label (Fenoprofen Calcium), Misemer Pharmaceuticals, Inc., effective August 20, 2026 (SPL set d33ad329-1ca6-ac2e-e053-2995a90a15c5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Fenoprofen | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Pain, Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once