What the FDA labels say about taking them together
Digoxin and esmolol
Esmolol's FDA label of March 14, 2025 names digoxin in its drug interactions section; digoxin's label does not name esmolol itself but warns about its class (Beta blockers). The esmolol label: “Digitalis glycosides: Concomitant administration of digoxin and BREVIBLOC injection leads to an approximate 10% to 20% increase of digoxin blood levels at some time points.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the esmolol FDA label on DailyMed (effective March 14, 2025, Baxter Healthcare Company).
What does the digoxin label say about esmolol?
Digoxin's label does not name esmolol itself; it warns about its class (Beta blockers):
Digoxin label, drug interactionsBeta-adrenergic blockers and calcium channel blockers Additive effects on AV node conduction can result in bradycardia and advanced or complete heart block.
Digoxin label, drug interactionsSupplements Calcium If administered rapidly by intravenous route, can produce serious arrhythmias in digitalized patients. Beta-adrenergic Blockers and Calcium Channel Blockers Additive effects on AV node conduction can result in complete heart block.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the esmolol label say about digoxin?
Esmolol label, drug interactionsDigitalis glycosides: Concomitant administration of digoxin and BREVIBLOC injection leads to an approximate 10% to 20% increase of digoxin blood levels at some time points.
Source: FDA drug label (Esmolol Hydrochloride In Water, NDA205703), WG Critical Care, LLC, effective May 31, 2024 (SPL set 60b10020-f802-4fef-a487-0f11eca246c5), via openFDA
Source: FDA drug label (Brevibloc), Baxter Healthcare Company, effective March 14, 2025 (SPL set 595cc3d5-1306-4828-aefa-5595219ffd62), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Esmolol | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | High blood pressure, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once