What the FDA labels say about taking them together
Digoxin and erythromycin
Erythromycin's FDA label of August 1, 2024 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name erythromycin. The erythromycin label: “Concomitant administration of erythromycin and digoxin has been reported to result in elevated digoxin serum levels.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.).
What does the digoxin label say about erythromycin?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name erythromycin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the erythromycin label say about digoxin?
Erythromycin label, drug interactionsConcomitant administration of erythromycin and digoxin has been reported to result in elevated digoxin serum levels.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Erythromycin | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Bacterial infections, Acne |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $1.96 per tablet 250 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once