What the FDA labels say about taking them together
Digoxin and epoprostenol
Digoxin's FDA label of December 5, 2024 names epoprostenol in its drug interactions section, and epoprostenol's label names digoxin too. The digoxin label: “Alprazolam, azithromycin, cyclosporine, diclofenac, diphenoxylate, epoprostenol, esomeprazole, ibuprofen, ketoconazole, lansoprazole, metformin, omeprazole; …”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the epoprostenol FDA label on DailyMed (effective November 28, 2022, Actelion Pharmaceuticals US, Inc.).
What does the digoxin label say about epoprostenol?
Digoxin label, drug interactionsAlprazolam, azithromycin, cyclosporine, diclofenac, diphenoxylate, epoprostenol, esomeprazole, ibuprofen, ketoconazole, lansoprazole, metformin, omeprazole; Measure serum digoxin concentrations before initiating concomitant drugs. Continue monitoring and reduce digoxin dose as necessary.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the epoprostenol label say about digoxin?
Epoprostenol label, drug interactionsIn a pharmacokinetic substudy in patients with congestive heart failure receiving furosemide or digoxin in whom therapy with epoprostenol was initiated, apparent oral clearance values for furosemide (n=23) and digoxin (n=30) were decreased by 13% and 15%, respectively, on the second day of therapy and had returned to baseline values by day 87.
Source: FDA drug label (Veletri), Actelion Pharmaceuticals US, Inc., effective November 28, 2022 (SPL set df502787-46ec-4dd1-a2c0-be90f6d95a5d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Epoprostenol | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Pulmonary arterial hypertension |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once