What the FDA labels say about taking them together
Digoxin and elagolix
Elagolix's FDA label of December 19, 2025 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name elagolix. The elagolix label: “Increase monitoring of digoxin concentrations and potential signs and symptoms of clinical toxicity when initiating ORILISSA in patients who are taking digoxin. …”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the elagolix FDA label on DailyMed (effective December 19, 2025, AbbVie Inc.).
What does the digoxin label say about elagolix?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name elagolix in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the elagolix label say about digoxin?
Elagolix label, drug interactionsConcomitant Drug Class/Drug Name: Cardiac glycosides: digoxin; Effect on Plasma Exposure of Concomitant Drug: ↑ digoxin; Clinical Recommendations: Increase monitoring of digoxin concentrations and potential signs and symptoms of clinical toxicity when initiating ORILISSA in patients who are taking digoxin. If ORILISSA is discontinued, increase monitoring of digoxin concentrations.
Source: FDA drug label (Orilissa), AbbVie Inc., effective December 19, 2025 (SPL set a86757b3-09c5-fd3b-1223-244e94f50a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Elagolix | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $43.81 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once