Diflunisal and Furosemide Interaction
Drug interaction information between Diflunisal and Furosemide.
Diflunisal and Furosemide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diflunisal and Furosemide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diflunisal can stop the water pill from helping the body get rid of extra salt. This makes the water pill less effective at reducing swelling or lowering blood pressure.
FDA Label Information
Diuretics Clinical studies, as well as postmarketing observations, have shown that diflunisal can reduce the natriuretic effect of furosemide and thiazides in some patients.
Diflunisal Also Interacts With
- Methotrexate moderate
- Cyclosporine moderate
- Celecoxib moderate
- Indomethacin moderate
- Mefenamic Acid moderate
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Diflunisal + Furosemide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Diflunisal's 17. In the minor band specifically: Diflunisal has 6 (also Hydrochlorothiazide, Aspirin, Acetaminophen, Lithium); Furosemide has 29 (also Methotrexate, Norepinephrine, Ethacrynic Acid, Indomethacin).
What mechanism field is on file for Diflunisal and Furosemide?
Diflunisal can stop the water pill from helping the body get rid of extra salt. This makes the water pill less effective at reducing swelling or lowering blood pressure.
Furosemide carries more major-labeled pairs than Diflunisal
SPL source-record counts only. This page's band is minor · classes on file: Diflunisal (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Furosemide (Loop Diuretic).
Furosemide has 3 major-labeled pairs vs Diflunisal's 0. This page itself is in the minor band, not the major band.
0 major · 11 moderate · 6 minor · 17 total
- Other minor peers for Diflunisal
- Hydrochlorothiazide
- Aspirin
- Acetaminophen
- Lithium
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Norepinephrine
- Ethacrynic Acid
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.