What the FDA labels say about taking them together
Dienogest/estradiol and voriconazole
Dienogest/estradiol's FDA label of June 26, 2024 names voriconazole in its drug interactions section; the voriconazole labels PlainMeds reads (3) do not name dienogest/estradiol. The dienogest/estradiol label: “Concomitant administration of moderate or strong CYP3A4 inhibitors like azole antifungals, verapamil, macrolides, diltiazem, and grapefruit increase the serum concentrations of both estradiol and dienogest.”
Check it at the source: the dienogest/estradiol FDA label on DailyMed (effective June 26, 2024, Bayer HealthCare Pharmaceuticals Inc.); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the dienogest/estradiol label say about voriconazole?
Dienogest/estradiol label, drug interactionsConcomitant administration of moderate or strong CYP3A4 inhibitors like azole antifungals (for example, ketoconazole, itraconazole, voriconazole, fluconazole), verapamil, macrolides (for example, clarithromycin, erythromycin), diltiazem, and grapefruit increase the serum concentrations of both estradiol and dienogest.
Source: FDA drug label (Natazia), Bayer HealthCare Pharmaceuticals Inc., effective June 26, 2024 (SPL set 02c91fba-9c47-43ef-ac78-e82369798834), via openFDA; the full label on DailyMed
What does the voriconazole label say about dienogest/estradiol?
Voriconazole's label (effective February 26, 2026) and its 2 other brand-application labels do not name dienogest/estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dienogest/estradiol | Voriconazole | |
|---|---|---|
| Labeled for | Birth control | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $8.46 per tablet 28 tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once