What the FDA labels say about taking them together
Dicyclomine and digoxin
Dicyclomine's FDA label of August 6, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name dicyclomine. The dicyclomine label: “… affecting on gastrointestinal motility, such as slowly dissolving dosage forms of digoxin; increased serum digoxin concentration may result.”
Check it at the source: the dicyclomine FDA label on DailyMed (effective August 6, 2026, Lannett Company, LLC); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the dicyclomine label say about digoxin?
Dicyclomine label, drug interactionsAbsorption of Other Drugs Anticholinergic agents may affect gastrointestinal absorption of various drugs by affecting on gastrointestinal motility, such as slowly dissolving dosage forms of digoxin; increased serum digoxin concentration may result.
Source: FDA drug label (Dicyclomine Hydrochloride), Lannett Company, LLC, effective August 6, 2026 (SPL set bd2cba10-70ec-4d1f-b46c-53d1de2ee130), via openFDA; the full label on DailyMed
What does the digoxin label say about dicyclomine?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name dicyclomine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dicyclomine | Digoxin | |
|---|---|---|
| Labeled for | Irritable bowel syndrome | Heart failure, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.059 per tablet 20 mg tablet | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once