What the FDA labels say about taking them together
Diclofenac and propranolol
Diclofenac's FDA label (Licart) of April 2, 2026 names propranolol in its drug interactions section; propranolol's label does not name diclofenac itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)).
Check it at the source: the diclofenac FDA label on DailyMed (effective February 11, 2025, Haleon US Holdings LLC); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the diclofenac label say about propranolol?
Licart label (IBSA Pharma Inc., April 2, 2026), drug interactionsACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers Clinical Impact: NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol). Clinical Impact: In patients who are elderly, volume-depleted (…), or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs … Intervention: During concomitant use of LICART and ACE-inhibitors, ARBs, or betablockers, monitor blood pressure to ensure that the desired blood pressure is obtained. During concomitant use of LICART and ACE-inhibitors or ARBs in patients who are elderly, volume-depleted, or have impaired renal function …
Source: FDA drug label (Licart, NDA206976), IBSA Pharma Inc., effective April 2, 2026 (SPL set 851c8b39-6056-4bbc-812e-b9b13977c1ac), via openFDA
Source: FDA drug label (Flector, NDA021234), IBSA Pharma Inc., effective October 21, 2025 (SPL set 1f19a016-c4fc-43c5-9990-e5f2e2776a82), via openFDA
Source: FDA drug label (Voltaren Arthritis Pain), Haleon US Holdings LLC, effective February 11, 2025 (SPL set 30a94282-0892-442a-aa10-6525cbd4fe88), via openFDA; the full label on DailyMed
What does the propranolol label say about diclofenac?
Propranolol's label does not name diclofenac itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Propranolol label, drug interactionsNon-Cardiovascular Drugs Nonsteroidal Anti-Inflammatory Drugs Nonsteroidal anti-inflammatory drugs (NSAIDS) have been reported to blunt the antihypertensive effect of beta-adrenoreceptor blocking agents.
Propranolol label, drug interactionsNonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effect of beta-adrenoreceptor blocking agents.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diclofenac | Propranolol | |
|---|---|---|
| Labeled for | Pain, Osteoarthritis, Rheumatoid arthritis, Migraine | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0619 per tablet 75 mg tablet | $0.0493 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once