What the FDA labels say about taking them together
Diazepam and propranolol
Diazepam's FDA label (Valtoco) of June 3, 2026 names propranolol in its drug interactions section, and propranolol's label names diazepam too. The propranolol label: “Benzodiazepines Propranolol can inhibit the metabolism of diazepam, resulting in increased concentrations of diazepam and its metabolites.”
Check it at the source: the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the diazepam label say about propranolol?
Valtoco label (Neurelis, Inc, June 3, 2026), drug interactionsMetabolism of Other Drugs Diazepam is a substrate for CYP2C19 and CYP3A4; therefore, it is possible that VALTOCO may interfere with the metabolism of drugs which are substrates for CYP2C19 (e.g., omeprazole, propranolol, and imipramine) and CYP3A4 (e.g., cyclosporine, paclitaxel, theophylline, and warfarin) leading to a potential drug-drug interaction.
Source: FDA drug label (Valtoco, NDA211635), Neurelis, Inc, effective June 3, 2026 (SPL set 1a8bcc90-68fa-474d-832c-0df01e825f39), via openFDA
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
What does the propranolol label say about diazepam?
Propranolol label, drug interactionsBenzodiazepines Propranolol can inhibit the metabolism of diazepam, resulting in increased concentrations of diazepam and its metabolites.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diazepam | Propranolol | |
|---|---|---|
| Labeled for | Anxiety, Muscle spasms and spasticity | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0283 per tablet 10 mg tablet | $0.0493 per tablet 20 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once