What the FDA labels say about taking them together
Diazepam and esomeprazole
Esomeprazole's FDA label (Esomeprazole Strontium) of September 22, 2016 names diazepam in its drug interactions section; the diazepam labels PlainMeds reads (4) do not name esomeprazole. The esomeprazole label: “Coadministration of esomeprazole 30 mg and diazepam, a CYP2C19 substrate, resulted in a 45% decrease in clearance of diazepam.”
Check it at the source: the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC); the esomeprazole FDA label on DailyMed (effective March 19, 2024, Haleon US Holdings LLC).
What does the diazepam label say about esomeprazole?
Diazepam's label (effective August 11, 2026) and its 3 other brand-application labels do not name esomeprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
What does the esomeprazole label say about diazepam?
Esomeprazole Strontium label (R2 Pharma, LLC, September 22, 2016), drug interactionsCoadministration of esomeprazole 30 mg and diazepam, a CYP2C19 substrate, resulted in a 45% decrease in clearance of diazepam.
Source: FDA drug label (Esomeprazole Strontium, NDA202342), R2 Pharma, LLC, effective September 22, 2016 (SPL set 3c916d32-f9e9-1d15-e054-00144ff88e88), via openFDA
Source: FDA drug label (Nexium 24HR), NDA204655 (Astrazeneca Lp), as published by Haleon US Holdings LLC, effective March 19, 2024 (SPL set 4513934d-0cf0-40fc-a348-b4e75a33b094), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Diazepam | Esomeprazole | |
|---|---|---|
| Labeled for | Anxiety, Muscle spasms and spasticity | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0283 per tablet 10 mg tablet | $0.145 per capsule 20 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once