What the FDA labels say about taking them together
Dextrose/potassium chloride and digoxin
Dextrose/potassium chloride's FDA label of July 15, 2019 names digoxin in its warnings and precautions section; the digoxin labels PlainMeds reads (3) do not name dextrose/potassium chloride. The dextrose/potassium chloride label: “Patients at increased risk of developing hyperkalemia and cardiac arrhythmias include those: with severe renal impairment, acute dehydration, extensive tissue injury or burns, and certain cardiac disorders such as …”
Check it at the source: the dextrose/potassium chloride FDA label on DailyMed (effective July 15, 2019, Baxter Healthcare Company); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the dextrose/potassium chloride label say about digoxin?
Dextrose/potassium chloride label, warnings and precautions• with severe renal impairment, acute dehydration, extensive tissue injury or burns, and certain cardiac disorders such as congestive heart failure or AV block (especially if they receive digoxin).
Potassium Chloride In Dextrose label (B. Braun Medical Inc., July 31, 2020), warnings and precautionsPatients at increased risk of developing hyperkalemia and cardiac arrhythmias include those: with severe renal impairment, acute dehydration, extensive tissue injury or burns, and certain cardiac disorders such as congestive heart failure or AV block (especially if they receive digoxin). with hyperosmolality, acidosis, or undergoing correction of alkalsis (conditions associated with a shift of potassium from intracellular to extracellular space). treated concurrently or recently with agents or products that can cause or increase the risk of hyperkalemia [see Drug Interactions (7.1)].
Source: FDA drug label (Potassium Chloride In Dextrose, NDA019699), B. Braun Medical Inc., effective July 31, 2020 (SPL set e5bbb3e1-ab50-4ec7-a2b4-ce4091712e23), via openFDA
Source: FDA drug label (Potassium Chloride in Dextrose), Baxter Healthcare Company, effective July 15, 2019 (SPL set 45de5402-5e61-4bbd-8bbc-5e3392c9920e), via openFDA; the full label on DailyMed
What does the digoxin label say about dextrose/potassium chloride?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name dextrose/potassium chloride in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dextrose/potassium chloride | Digoxin | |
|---|---|---|
| Labeled for | n/a | Heart failure, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once