What the FDA labels say about taking them together
Dextroamphetamine and protriptyline
Dextroamphetamine's FDA label of November 26, 2025 names protriptyline in its drug interactions section; the protriptyline label PlainMeds reads does not name dextroamphetamine. The dextroamphetamine label: “Antidepressants, Tricyclic Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d -amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained …”
Check it at the source: the dextroamphetamine FDA label on DailyMed (effective November 26, 2025, Azurity Pharmaceuticals, Inc.); the protriptyline FDA label on DailyMed (effective July 25, 2023, Epic Pharma, LLC).
What does the dextroamphetamine label say about protriptyline?
Dextroamphetamine label, drug interactionsAntidepressants, Tricyclic Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d -amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d -amphetamine in the brain; cardiovascular effects can be potentiated.
Source: FDA drug label (Zenzedi), Azurity Pharmaceuticals, Inc., effective November 26, 2025 (SPL set d6394df5-f2c9-47eb-b57e-f3e9cfd94f84), via openFDA; the full label on DailyMed
What does the protriptyline label say about dextroamphetamine?
Protriptyline's label (effective July 25, 2023) does not name dextroamphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Protriptyline Hydrochloride), Epic Pharma, LLC, effective July 25, 2023 (SPL set c6c7c39e-e510-4f4a-bf7a-926f0e075d3a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dextroamphetamine | Protriptyline | |
|---|---|---|
| Labeled for | ADHD | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.373 per tablet 10 mg tablet | $2.71 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once