What the FDA labels say about taking them together
Deutivacaftor/tezacaftor/vanzacaftor and warfarin
Deutivacaftor/tezacaftor/vanzacaftor's FDA label of August 26, 2026 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name deutivacaftor/tezacaftor/vanzacaftor. The deutivacaftor/tezacaftor/vanzacaftor label: “Monitor the international normalized ratio (INR) more frequently with concomitant use of ALYFTREK with warfarin.”
Check it at the source: the deutivacaftor/tezacaftor/vanzacaftor FDA label on DailyMed (effective August 26, 2026, Vertex Pharmaceuticals Incorporated); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the deutivacaftor/tezacaftor/vanzacaftor label say about warfarin?
Deutivacaftor/tezacaftor/vanzacaftor label, drug interactionsMonitor the international normalized ratio (INR) more frequently with concomitant use of ALYFTREK with warfarin.
Source: FDA drug label (ALYFTREK), Vertex Pharmaceuticals Incorporated, effective August 26, 2026 (SPL set 7e635909-c6fd-4f0d-ae77-cdff03653a20), via openFDA; the full label on DailyMed
What does the warfarin label say about deutivacaftor/tezacaftor/vanzacaftor?
Warfarin's label (effective May 29, 2026) does not name deutivacaftor/tezacaftor/vanzacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Deutivacaftor/tezacaftor/vanzacaftor | Warfarin | |
|---|---|---|
| Labeled for | n/a | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once