What the FDA labels say about taking them together
Desloratadine and loratadine
Desloratadine's FDA label of May 17, 2025 names loratadine in its contraindications section; the loratadine label PlainMeds reads does not name desloratadine. The desloratadine label: “CONTRAINDICATIONS CLARINEX Tablets, RediTabs, and Oral Solution are contraindicated in patients who are hypersensitive to this medication or to any of its ingredients or to loratadine.”
Check it at the source: the desloratadine FDA label on DailyMed (effective May 17, 2025, Organon LLC); the loratadine FDA label on DailyMed (effective December 5, 2025, Bayer HealthCare LLC.).
What does the desloratadine label say about loratadine?
Desloratadine label, contraindicationsCONTRAINDICATIONS CLARINEX Tablets, RediTabs, and Oral Solution are contraindicated in patients who are hypersensitive to this medication or to any of its ingredients or to loratadine [see Warnings and Precautions (5.1) and Adverse Reactions (6.2) ].
Source: FDA drug label (Clarinex), Organon LLC, effective May 17, 2025 (SPL set c671342e-69a2-4ca5-abc2-8166ed4240d4), via openFDA; the full label on DailyMed
What does the loratadine label say about desloratadine?
Loratadine's label (effective December 5, 2025) does not name desloratadine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Claritin), Bayer HealthCare LLC., effective December 5, 2025 (SPL set 660ac9df-f1b1-4c89-94dd-9fae0a013f3c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Desloratadine | Loratadine | |
|---|---|---|
| Labeled for | Allergies | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.258 per tablet 5 mg tablet | $0.0529 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once