What the FDA labels say about taking them together
Delafloxacin and glyburide
Delafloxacin's FDA label of August 1, 2025 names glyburide in its warnings and precautions section; glyburide's label does not name delafloxacin itself but warns about its class (Fluoroquinolones). The delafloxacin label: “… patients receiving concomitant treatment with an oral hypoglycemic agent (e.g., glyburide) or with insulin.”
Check it at the source: the delafloxacin FDA label on DailyMed (effective August 1, 2025, Melinta Therapeutics, LLC); the glyburide FDA label on DailyMed (effective July 1, 2021, TEVA Pharmaceuticals USA Inc).
What does the delafloxacin label say about glyburide?
Delafloxacin label, warnings and precautionsFluoroquinolones have been associated with disturbances of blood glucose, including symptomatic hyperglycemia and hypoglycemia, usually in diabetic patients receiving concomitant treatment with an oral hypoglycemic agent (e.g., glyburide) or with insulin.
Source: FDA drug label (Baxdela), Melinta Therapeutics, LLC, effective August 1, 2025 (SPL set fb77637a-88d9-4aea-958f-e270030ce30d), via openFDA; the full label on DailyMed
What does the glyburide label say about delafloxacin?
Glyburide's label does not name delafloxacin itself; it warns about its class (Fluoroquinolones):
Glyburide label, drug interactionsA possible interaction between glyburide and fluoroquinolone antibiotics has been reported resulting in a potentiation of the hypoglycemic action of glyburide.
Source: FDA drug label (Glyburide), NDA017532 (Sanofi Aventis Us), as published by TEVA Pharmaceuticals USA Inc, effective July 1, 2021 (SPL set 50d16f1d-c814-4411-8749-62561321ecce), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Delafloxacin | Glyburide | |
|---|---|---|
| Labeled for | n/a | Type 2 diabetes |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.0643 per tablet 5 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once