What the FDA labels say about taking them together
Darunavir and timolol
Darunavir's FDA label of August 29, 2025 names timolol in its drug interactions section; the timolol labels PlainMeds reads (4) do not name darunavir. The darunavir label: “Clinical monitoring of patients is recommended. A dose decrease may be needed for these drugs when co-administered with PREZISTA/ritonavir and a lower dose of the beta blocker should be considered.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the timolol FDA label on DailyMed (effective June 27, 2025, Thea Pharma Inc.).
What does the darunavir label say about timolol?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: β-Blockers: e.g. carvedilol, metoprolol, timolol; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ beta-blockers; Clinical Comment: Clinical monitoring of patients is recommended. A dose decrease may be needed for these drugs when co-administered with PREZISTA/ritonavir and a lower dose of the beta blocker should be considered.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the timolol label say about darunavir?
Timolol's label (effective June 27, 2025) and its 3 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BETIMOL), Thea Pharma Inc., effective June 27, 2025 (SPL set 3ae775f4-340c-4bf4-aa49-8a31daba0f8b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Timolol | |
|---|---|---|
| Labeled for | HIV | Glaucoma, High blood pressure, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.774 per mL 0.5% eye drops |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once