What the FDA labels say about taking them together
Darunavir and thioridazine
Darunavir's FDA label of August 29, 2025 names thioridazine in its drug interactions section; the thioridazine label PlainMeds reads does not name darunavir. The darunavir label: “A decrease in the dose of antipsychotics that are metabolized by CYP3A or CYP2D6 may be needed when co-administered with PREZISTA/ritonavir.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the thioridazine FDA label on DailyMed (effective November 11, 2025, Mylan Institutional Inc.).
What does the darunavir label say about thioridazine?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: e.g. perphenazine, risperidone, thioridazine; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ antipsychotics; Clinical Comment: A decrease in the dose of antipsychotics that are metabolized by CYP3A or CYP2D6 may be needed when co-administered with PREZISTA/ritonavir.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the thioridazine label say about darunavir?
Thioridazine's label (effective November 11, 2025) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Thioridazine Hydrochloride), Mylan Institutional Inc., effective November 11, 2025 (SPL set 52fea941-0b47-41c1-b00d-f88150e8ab93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Thioridazine | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.571 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once