What the FDA labels say about taking them together
Darunavir and diltiazem
Darunavir's FDA label of August 29, 2025 names diltiazem in its drug interactions section; the diltiazem labels PlainMeds reads (4) do not name darunavir. The darunavir label: “Clinical monitoring of patients is recommended.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the diltiazem FDA label on DailyMed (effective August 7, 2026, Bausch Health US, LLC).
What does the darunavir label say about diltiazem?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: Calcium Channel Blockers: amlodipine, diltiazem, felodipine, nicardipine, nifedipine, verapamil; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ calcium channel blockers; Clinical Comment: Clinical monitoring of patients is recommended.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the diltiazem label say about darunavir?
Diltiazem's label (effective August 7, 2026) and its 3 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Diltiazem | |
|---|---|---|
| Labeled for | HIV | High blood pressure, Angina, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.144 per capsule 24h ER(cd) 120 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once