What the FDA labels say about taking them together
Clonazepam and darunavir
Darunavir's FDA label of August 29, 2025 names clonazepam in its drug interactions section; the clonazepam label PlainMeds reads does not name darunavir. The darunavir label: “Clinical monitoring of anticonvulsants that are metabolized by CYP3A is recommended.”
Check it at the source: the clonazepam FDA label on DailyMed (effective December 1, 2025, H2-Pharma, LLC); the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP).
What does the clonazepam label say about darunavir?
Clonazepam's label (effective December 1, 2025) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Klonopin), NDA017533 (Cheplapharm), as published by H2-Pharma, LLC, effective December 1, 2025 (SPL set cfa0d79a-843c-4b88-95a1-e9511d649ca1), via openFDA; the full label on DailyMed
What does the darunavir label say about clonazepam?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: clonazepam; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ clonazepam; Clinical Comment: Clinical monitoring of anticonvulsants that are metabolized by CYP3A is recommended.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonazepam | Darunavir | |
|---|---|---|
| Labeled for | Seizures and epilepsy, Anxiety | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0244 per tablet 1 mg tablet | $1.16 per tablet 600 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once