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What the FDA labels say about taking them together

Darifenacin and nelfinavir

Darifenacin's FDA label of February 10, 2026 names nelfinavir in its drug interactions section; the nelfinavir label PlainMeds reads does not name darifenacin. The darifenacin label: “The daily dose of darifenacin extended-release tablets should not exceed 7.5 mg when co-administered with potent CYP3A4 inhibitors.”

Check it at the source: the darifenacin FDA label on DailyMed (effective February 10, 2026, Torrent Pharmaceuticals Limited); the nelfinavir FDA label on DailyMed (effective December 11, 2025, AGOURON).

What does the darifenacin label say about nelfinavir?

Darifenacin label, drug interactions

The daily dose of darifenacin extended-release tablets should not exceed 7.5 mg when co-administered with potent CYP3A4 inhibitors (for example, ketoconazole, itraconazole, ritonavir, nelfinavir, clarithromycin and nefazadone).

Source: FDA drug label (Darifenacin), Torrent Pharmaceuticals Limited, effective February 10, 2026 (SPL set e84f1ae3-b9a2-4a15-a299-c75373891cc1), via openFDA; the full label on DailyMed

What does the nelfinavir label say about darifenacin?

Nelfinavir's label (effective December 11, 2025) does not name darifenacin in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (VIRACEPT), AGOURON, effective December 11, 2025 (SPL set e72c2bc6-9462-4a2e-8e1d-b97592376cbd), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

8Darifenacin generic labelers
0Nelfinavir generic labelers
DarifenacinNelfinavir
Labeled forOveractive bladderHIV
Boxed warningNoNo
Pharmacy cost (NADAC)$0.432 per tablet 15 mg tabletn/a
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?